Emerging Infectious Disease Network
Transmissible
Spongiform Encephalopathies (TSE)
The Transmissible
Spongiform Encephalopathies Reference Library is a collaborative initiative
of international veterinary, medical and scientific experts to share information
and enhance academic discussion of emerging infectious diseases and issues
associated with preparedness, response, mitigation and policy. ..... ..... ..... ..... ..... ..... ..... ...... ..... .....
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In the Spotlight
- Research indicates mad cow pathogen can cause both sporadic
or classical Creutzfeldt-Jacob disease (CJD) and varient form: May 7 (HRI)
- Call for International Action by the World Organization for Animal Health
(OIE), Food and Agriculture Organization of the United Nations (FAO) and
World Health Organization (WHO).
- Transmissible Spongiform Encephalopathies (BSE) in North America:
Humanitarian Resource Institute.
- Risk
Analysis of prion disease in animals: C.I. Lasmézas &
D.B. Adams (eds), OIE, Scientific and Technical Review, Volume 22 (1), April
2003.
- Advancing Prion Science: Guidance for the National Prion Research
Program (2003): National Academy of Sciences
- EU Geographical BSE Risk Assessment: Country Reports,
Outcome of discussions: Opinions - Minutes.
- Genome Affects Human Forms of “Mad Cow” Disease: Genome
News Network (GNN), 23 January 2004.
- Agent Summary Statements, Section VII-D: Prions, CDC:
Office of Health and Safety (OHS), BMBL Section VII.
The GNN article speculates that the chance of developing
a human prion disease in any form is less than one in a million. This statistic
is being challenged by research at Yale University (Medline) that found 13 percent of Alzheimer's patients
actually had CJD and potential association with BSE prion propagation as either
variant CJD-like or sporadic CJD-like prion strains (demonstrated in transgenic mice expressing human prion protein).
For additional information on genomics research, visit the HRI Bioinformatics: Pathological Diagnostics web site.
Food &
Agriculture Organization of the United Nations
- Bovine Spongiform
Encephalopathy (Mad Cow Disease): FAO recommends precautions FAO estimates
that between 1986-96 up to today, meat and bone meal (MBM) from Europe was
exported to more than 100 countries. Around 100 countries imported
live cattle. Some countries also re-exported MBM to third countries. All
countries which have imported cattle or meat and bone meal that originated
from Western Europe, during and since the 1980s, can be therefore considered
at risk from the disease. Regions that have imported sizeable quantities
of meat meal from the UK during and since the 1980s include the Near East,
Eastern Europe and Asia.
TSE Educational
Resources:
General Veterinary
Research & Publications
General Information: Emerging Infectious Diseases
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